Acceleron Pharma, Inc. (XLRN) – Sotatercept

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Briefing

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Recognizing that many of the historical (SOC) agents have been approved for use based on 6-minute walk as a primary, is it concerning that the current trial has demoted 6MW to a secondary? Curious also if other indications are planned down the road, like CTEPH…

Sotatercept was first used to modulate TGFb signaling associated with erythropoesis (thru 2015) and was replaced by luspatercept – which went on to be approved. Seems they pivoted to hypothesis for PAH, which is preclinically well founded in nice work highlighted here: https://acceleronpharma.com/wp-content/uploads/2017/11/Dr.-Yu-Presentation-AHA-17-1.pdf

preclinical data suggests this approach is superior to use of PDE5 inhibitors (sildenafil, tadalafil) which have gained common use alone or in combination with vasodilator or endothelin receptor antagonist.

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Click to answer the Acceleron-Sotatercept Follow-up Questions

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Here are what everyone submitted initially:   Summary of Initial Asssessments

 

 

Initial Assessment

Supporting Materials

Acceleron Website